Technology and cybersecurity

Executive Order 14081: Advancing Biotechnology and Biomanufacturing Innovation for a Sustainable, Safe, and Secure American Bioeconomy

President: Joseph R. Biden Jr.

Directed agencies to expand domestic biomanufacturing, research, data infrastructure, workforce, procurement and biosafety while reducing supply-chain dependence.

Status: Revoked. Is Executive Order 14081 still in effect? No. Executive Order 14081 was revoked. See Federal Register record.

What does Executive Order 14081 do?

Agencies were assigned biotechnology assessments and plans; standards, data, procurement and manufacturing decisions required their own follow-up.

Administration position: The order’s findings and policy rationale were the Biden administration’s positions. This guide distinguishes them from implementation records and judicial rulings.
SignedSeptember 12, 2022
Lead officialsWhite House science and security staff, Commerce, Defense, HHS, Energy and Agriculture
Express timingAgency assessments and plans within 90–365 days

Before and after

Before the order

Federal biotechnology programs were dispersed across health, agriculture, energy, defense and science agencies without a unified bioeconomy plan.

After the order

Agencies issued bold-goals reports, procurement initiatives and investments in domestic capacity. The 2025 administration revoked or redirected related climate and equity priorities and issued new biotechnology policy; underlying grants, statutes and completed investments require separate treatment.

Who had to do what

Agency / officeActionTiming / position
AgenciesAssess biotechnology needs and set bold goals180 days
Commerce and standards agenciesDevelop measurement and data infrastructureOngoing
Defense and HHSInvest in resilient domestic biomanufacturingStaged plans

What happened next

EO 14081 signed.